Científicos del Hospital de La Candelaria participan en el descubrimiento de un gen asociado a la fibrosis pulmonar

Carlos Flores y Beatriz Guillén, de la Unidad de Investigación Hospital Universitario Nuestra Señora de Candelaria.

The Lancet Respiratory Medicine, la revista científica de mayor impacto en este campo, recoge en su versión digital los avances realizados en este campo por un grupo internacional de investigadores.

Esta patología debilita al paciente dificultando su respiración y afecta a 6000 personas cada año, sin cura en la actualidad.

Científicos de la Unidad de Investigación del Hospital Universitario Nuestra Señora de Candelaria, en Tenerife, adscrito a la Consejería de Sanidad del Gobierno de Canarias, han colaborado en el descubrimiento de un gen asociado a la fibrosis pulmonar idiopática (FPI), y cuyo estudio abre una nueva vía potencial para el tratamiento de esta enfermedad.

Los resultados de esta investigación liderada por la Universidad de Leicester (Reino Unido), en la que participaron Carlos Flores y Beatriz Guillén, se han publicado recientemente en la revista The Lancet Respiratory Medicine, de gran impacto científico, bajo el título ‘Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study’.

La investigación revela que las personas con alteraciones en el gen AKAP13 están más expuestas a desarrollar esta enfermedad pulmonar y cómo este gen afecta a la proteína producida en el pulmón.

Los científicos de la Unidad de Investigación del Hospital Universitario Nuestra Señora de Candelaria son los únicos españoles que han colaborado en esta investigación internacional, en la que se ha analizado el ADN procedente de más de 2700 personas con fibrosis pulmonar idiopática y 8500 personas sin esta enfermedad, de diversos países, siendo el mayor estudio genético de esta patología realizado hasta el momento.

Se trata de un trabajo internacional en el que participan científicos de diferentes departamentos, como por ejemplo, de las universidades de Nottingham (Reino Unido), Colorado (EEUU), California (EEUU), Chicago (EEUU),  British Columbia Británica (Canadá), así como de las instituciones inglesas de Oxford, Edimburgo, Cambridge o Bristol, entre otras.

Fibrosis Pulmonar Idiopática

La fibrosis pulmonar idiopática es una enfermedad respiratoria, progresiva y crónica de origen aún desconocido, que presenta una alta mortalidad y para la que no existe todavía un tratamiento válido ni efectivo para su curación, salvo el trasplante de pulmón. Los últimos estudios revelan que existe un riesgo genético significativo asociado con el desarrollo de esta patología.

En palabras del Dr. Carlos Flores, “por estudios anteriores se conocía el papel de AKAP13 en el proceso de generación de fibrosis (cicatrización) y que tal proceso es susceptible de ser tratado con fármacos ya existentes en el mercado. Por ello, estos nuevos resultados apoyan la posibilidad de que AKAP13 pueda ser una nueva diana terapéutica para combatir la fibrosis pulmonar idiopática, actualmente sin cura”.


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